• Role of Non-coding RNAs in chemotherapeutic treatments
  • Ruolo dei Non coding RNAs nei trattamenti chemioterapici
  • Vannini, Ivan <1975>

Subject

  • BIO/14 Farmacologia

Description

  • The transcribed ultraconserved regions (T-UCRs) are a group of long non-coding RNAs involved in human carcinogenesis. The factors regulating the expression of T-UCRs and their mechanism of action in human cancers are unknown. In this work it was shown that high expression of uc.339 associates with lower survival in 204 non-small cell lung cancer (NSCLC) patients. Moreover, it was shown that uc.339 found up-regulated in archival NSCLC samples, acts as a decoy RNA for miR-339-3p, -663-3p and -95-5p. So, Cyclin E2, a direct target of three microRNAs is up-regulated, inducing cancer growth and migration. Evidence of this mechanism was provided from cell lines and primary samples confirming that TP53 directly regulates uc.339. These results support a key role for uc.339 in lung cancer.

Date

  • 2015-04-14

Type

  • Doctoral Thesis
  • PeerReviewed

Format

  • application/pdf

Identifier

urn:nbn:it:unibo-13961

Vannini, Ivan (2015) Ruolo dei Non coding RNAs nei trattamenti chemioterapici, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze farmacologiche e tossicologiche, dello sviluppo e del movimento umano , 27 Ciclo. DOI 10.6092/unibo/amsdottorato/6866.

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