- Analysis of Perfluoroalkyl Substances and Glycine Betaine: Contribution to the Assessment of Health Risks and Benefits of Seafood Consumption
- Farabegoli, Federica <1986>
Subject
- VET/04 Ispezione degli alimenti di origine animale
Description
- Seafood is known for its valuable and healthy nutrients; however scientific studies demonstrated the unavoidable presence of contaminants in fish and shellfish. Authorities strongly recommend fish consumption, especially to sensible groups of population (pregnant or nursing women, infants and children), and ask the scientific community for novel and coherent data to establish clear guidelines for consumers. There is also a serious need to extend the monitoring to emerging chemical pollutants, other than methylmercury, dioxins and polychlorinated biphenyls, to better understand the level of seafood contamination. An innovative UHPLC-MS/MS method for the quantification of glycine betaine (GB) in Tapes philippinarum was developed and validated, taking the 2002/657 European Decision as guideline; GB is an endogenous osmolyte abundant in molluscs, and represent a vital methylating agent in humans. Moreover, a previously developed and validated UHPLC-MS/MS method was used to conduct a preliminary monitoring of the presence of the two main perfluorinated contaminants, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), in six fish species from Italian markets (Dicentrarchus labrax, Merluccius merluccius, Mugil cephalus, Pleuronectes platessa, Scomber scombrus and Sparus aurata). The daily contribution of seafood to PFOS and PFOA dietary intake in Italian population was calculated and data were compared to the corresponding Tolerable Daily Intakes established by EFSA in 2008. Results revealed that the risk of contamination related to fish consumption is unlikely, but suggested the need to conduct further surveys focused on certain species from different sampling site. Subsequently, a mono-specie monitoring was carried out in 140 farmed and wild subjects of Dicentrarchus labrax, from 14 different locations in the Mediterranean area. The obtained results showed that wild subjects are sensibly more contaminated than farmed ones, and that levels of fish contamination are strongly influenced by their geographical origin and the proximity to polluted areas.
Date
- 2016-05-03
Type
- Doctoral Thesis
- PeerReviewed
Format
- application/pdf
Identifier
urn:nbn:it:unibo-18622
Farabegoli, Federica (2016) Analysis of Perfluoroalkyl Substances and Glycine Betaine: Contribution to the Assessment of Health Risks and Benefits of Seafood Consumption, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Scienze veterinarie