- Il ruolo dell'ecografia prenatale nell'infezione congenita da Citomegalovirus
- Simonazzi, Giuliana <1973>
Subject
- MED/40 Ginecologia e ostetricia
Description
- OBJECTIVE: To assess the effectiveness of ultrasound in the antenatal prediction of symptomatic congenital cytomegalovirus infection. STUDY DESIGN: The sonograms of 650 fetuses from mothers with primary cytomegalovirus infection were correlated to fetal/neonatal outcome. Infection status was disclosed by viral urine isolation at birth or CMV tissue inclusions at autopsy. Classification of symptomatic disease was based on postnatal clinical/laboratory findings or macroscopic evidence of tissue damage at autopsy. RESULTS: Ultrasound abnormalities were found in 51/600 (8.5%) mothers with primary infection and in 23/154 congenitally infected fetuses (14.9%). Symptomatic congenital infection resulted in 18/23 and 68/131 cases with or without abnormal sonographic findings, respectively. Positive predictive values of ultrasound versus symptomatic congenital infection was 35.3% relating to all fetuses/infants from mothers with primary infection and 78.3% relating to fetuses/infants with congenital infection. CONCLUSION: When fetal infection status is unknown, ultrasound abnormalities only predict symptomatic congenital infection in a third of cases.
Date
- 2008-06-09
Type
- Doctoral Thesis
- PeerReviewed
Format
- application/pdf
Identifier
urn:nbn:it:unibo-939
Simonazzi, Giuliana (2008) Il ruolo dell'ecografia prenatale nell'infezione congenita da Citomegalovirus, [Dissertation thesis], Alma Mater Studiorum Università di Bologna. Dottorato di ricerca in Medicina materno infantile e dell'età evolutiva